Evaluation of Anti-fibrotic effect of Lagerstroemia Speciosa (L) pers. on Carbon Tetrachloride Induced Liver Fibrosis

This study was carried out to investigate the effect of alcoholic extract of Lagerstroemia speciosa (L) pers. against carbon tetrachloride (CCl4) induced liver fibrosis in male albino Wistar rats (150-200gm). Liver fibrosis was induced by twice/week administration of CCl4 at a dose of 1ml/kg body weight, mixed with an equal volume of corn oil. The extent of liver fibrosis was assessed by the content of hydroxyproline in liver, serum level of Asparate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Billirubin and by histological studies. Treatment with alcoholic extract of Lagerstroemia speciosa (L) pers. (100 mg/kg body weight) orally, reduced the hydroxyproline content of the liver, various serum enzymes level and total billirubin. The architecture of liver deranged by CCl4 showed improvement following administration of the extract. These observations confirm the potent antifibrotic effect of the extract.